Unraveling the Immunologic Vulnerabilities of Diffuse Hemispheric Glioma H3 G34 Mutant DHG-G34


Robert Galvin, Negar Sadeghipour, Joanne Xiu, David M. Ashley, Manmeet Ahluwalia, Sonikpreet Aulakh, R. Stephanie Huang, David A Largaespada


  • DHG-G34 is an incurable brain cancer of adolescents and young adults, with no targeted treatmentDHG-G34 is susceptible to localized genome instability near mutated nucleosomes (A)
  • Uncovering mechanisms of immune escape may lead to a shift in treatment approach
  • Caris Life Sciences has accumulated a large cohort of DHG-G34 omics, permitting an exploration of the molecular and immune landscapes
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