Whole Exome Sequencing

Whole Exome Sequencing is a high-throughput, next generation sequencing-based assay analyzing the whole human exome of approximately 22,000 DNA genes.

Whole Exome Sequencing

Whole Exome Sequencing is a high-throughput, next generation sequencing-based assay analyzing the whole human exome of approximately 22,000 DNA genes. Caris’ MI Exome detects DNA Point Mutations, Insertions and Deletions, Copy Number Alterations, Loss of Heterozygosity (LOH), Microsatellite Instability (MSI), Tumor Mutational Burden (TMB) and Human Leukocyte Antigen (HLA) genotyping, all from one streamlined test. The assay integrates a 250,000 evenly-spaced genomic single nucleotide polymorphism (SNP) backbone to enhance detection of genome-level alterations, gene gain/loss and genome-wide instability.

The exons are the 1-2% of the genome that encode the proteins
Exome = Total exons of the genome

Example Gene

Combined with Caris MI Transcriptome Whole Transcriptome RNA Sequencing, extensive proteomic testing services, and advanced machine-learning capabilities, Caris molecular profiling is the most comprehensive and clinically relevant molecular profile for cancer patients in the industry.

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Whole Exome Sequencing (WES) DNA

  • 22,000 genes
  • 1,000x for 720+ clinical and research genes and 500x for all other genes
  • SNVs, indels and copy number alterations
  • 250,000 evenly-spaced genomic SNP
  • Genomic signatures
    • Loss of Heterozygosity (LOH)
    • Microsatellite Instability (MSI)
    • Tumor Mutational Burden (TMB)
  • Other
    • HLA Genotype*

*Not available in New York state.

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Whole Transcriptome Sequencing (WTS) RNA

  • 22,000 genes
  • 60 million read count
  • Gene fusions and variant transcripts
  • Novel translocation detection independent of intronic breakpoint

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Complete Gene Coverage with Caris Molecular Testing

As the pioneer in precision medicine, Caris was the first to provide comprehensive Whole Exome and Whole Transcriptome sequencing for every patient. Each Caris molecular profiling order includes next-generation sequencing of all 22,000 genes.

Looking for a specific gene? Use the full gene search below to verify that it is included in Caris profiling, or browse the list of genes most commonly associated with cancer.

Order a test

Place an order today for a comprehensive, personalized Caris profiling report.