Caris Assure Blood Based Profiling

Less Invasive, More Intelligent Than Ever


Be Sure with Caris Assure

With deep molecular insights from a simple blood sample, Caris Assure™ offers a minimally-invasive liquid biopsy option for biomarker analysis of cancer patients when tissue samples are not available. No matter the specimen type – tissue or blood – Caris Life Sciences’ flexible, multi-faceted molecular profiling platforms deliver uncompromising reliability and performance to guide personalized treatment decisions and help improve patient outcomes.*

The Most Powerful Liquid Biopsy Assay Ever Developed.

Circulating Nucleic Acid Sequencing

Biomarker Analysis (including resistance mutations)

Biological Coverage
Plasma: cfDNA, cfRNA
White Blood Cells: gDNA, mRNA

Variant Coverage (pathogenic and likely pathogenic)
Tumor-Derived   Incidental Germline†    Incidental CHIP

Genes & Depth
23,000+  8,000x (raw average for clinically relevant genes)

Next Generation Sequencing
Whole Exome
Whole Transcriptome

SNV  INDEL  CNA  Fusions

Genomic Signatures/Other
bTMB  HLA Genotype  MSI

Sample Quantity
Two Tubes Whole Blood

Performance in Advanced/Metastatic Patients
Compared to matched tissue collected within 30 days; based on ≥5 ng of cNAS input.
Clinically Actionable SNV and INDEL:
Sensitivity 93.8%
Specificity >99.9%
PPV 96.8%
LOD 0.1% VAF
Incidental Germline :
Sensitivity >99%
Specificity >99%
PPV >99%

Whole Exome and Whole Transcriptome Sequencing from Blood

Caris Assure analyzes 23,000+ genes using whole exome and whole transcriptome sequencing, providing the most robust and accurate assessment of the key molecular features of a patient’s cancer. This comprehensive approach identifies all pan-cancer biomarkers, including a wide range of variant types and genomic signatures. 

Tumor-Derived, Incidental Germline and Incidental CHIP Detection in a Single Assay

Caris Assure analyzes both plasma and buffy coat (white blood cell) layers, distinguishing tumor-derived somatic variants from incidental germline or incidental CHIP variants. The Caris Assure report subtracts incidental CHIP mutations from somatic tumor mutations to reduce false positives and improve assay reliability.

Looking for a Specific Gene?

Use our full gene search to verify that it is included in Caris profiling, or browse the list of genes most commonly associated with cancer.

Search Genes >

Liquid Profiling Blood Plasma Buffy Coat Testing Image

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* Caris Assure is intended for patients with previously diagnosed solid malignant neoplasms where tissue is not available, and is to be used by qualified healthcare professionals. Not available in all locations.

† Not a replacement for comprehensive germline testing. Incidental pathogenic alterations detected in ACMG recognized cancer genes are reported. Negative results do not imply the patient does not harbor a germline mutation.

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Place an order today for a comprehensive, personalized Caris profiling report.