Caris molecular profiling includes microsatellite instability (MSI) testing via next-generation sequencing (NGS).
Caris molecular profiling includes microsatellite instability (MSI) testing via next-generation sequencing (NGS). MSI is caused by failure of the DNA mismatch repair (MMR) system. High levels of MSI correlate to an increased neoantigen burden, which may make the tumor more sensitive to immunotherapy. MSI status is reported on pages one and two of the Caris Report, as well as in the NGS section in the Appendix.
Earlier studies have associated MSI-High status with benefit to immunotherapy in metastatic colorectal cancer. Additional data show that MSI is a useful indicator for predicting response to pembrolizumab in any solid tumor type.1
|Concordance Data: PCR vs NGS2|
Traditional Approach: normal and cancer tissue required
Caris Approach: no normal tissue required; saving resources, costs and time
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