The HLA System Regulates the Immune System
Human Leukocyte Antigen (HLA) is a group of related proteins that are encoded by the major histocompatibility complex (MHC) genes in humans. These cell-surface proteins are largely responsible for the regulation of the immune system. The MHCs are characterized as Class I and Class II that differ by function and dimerization (binding) patterns.
The proteins encoded by HLAs are those on the outer part of body cells that are unique to that person. The immune system uses the HLAs to differentiate self-cells and non-self-cells. Any cell displaying that person’s HLA type belongs to that person and, therefore, is not an invader.1
HLA Genotyping* is included with all Caris orders and is performed using Whole Exome Sequencing. Understanding a patient’s complete profile through Caris molecular profiling not only provides the most comprehensive genomic profile that can help identify the best course of today’s treatment, but it can continue to enhance a provider’s clinical approach as evidence evolves.
There is ongoing research that observed a correlation between patients’ HLA genotype with a response to checkpoint blockade immunotherapy. A patient’s genotype may also direct them to clinical trials recruiting for specific genotypes. Understanding patient HLA genotypes can be utilized in the development of both personalized cancer vaccine development as well as in the immunotherapy biomarker discovery.
*Not available in New York State.
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