The Prevalence of Sickle Cell Phenotype and its Association with Clinical Outcomes in persons of African descent with Solid Malignancies


Brianna Bakow, Harris Krause, Andrew Elliott, Gerald Soff, Asaad Trabolsi, Emmanuel Antonarakis, Matthew Oberley, Stephanie Graff


  • Sickle cell disease (SCD) is the most common inherited blood disorder in the United States and is caused by a mutation of β-globin (HBB MT).
  • The risk of developing solid malignancies in this population remains controversial.
  • We report the prevalence of HBB mutations across a cohort of solid tumors and clinical outcomes between HBB-Wild type (WT) v Mutant (MT) tumors.
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