The Prevalence of Sickle Cell Phenotype and its Association with Clinical Outcomes in persons of African descent with Solid Malignancies

Authors:

Brianna Bakow, Harris Krause, Andrew Elliott, Gerald Soff, Asaad Trabolsi, Emmanuel Antonarakis, Matthew Oberley, Stephanie Graff

Background

  • Sickle cell disease (SCD) is the most common inherited blood disorder in the United States and is caused by a mutation of β-globin (HBB MT).
  • The risk of developing solid malignancies in this population remains controversial.
  • We report the prevalence of HBB mutations across a cohort of solid tumors and clinical outcomes between HBB-Wild type (WT) v Mutant (MT) tumors.
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