The landscape of DNA damage response (DDR) pathway in colorectal cancer (CRC)


Hiroyuki Arai, Andrew Elliott, Joanne Xiu, Jingyuan Wang, Francesca Battaglin, Shivani Soni, Wu Zhang, Davendra Sohal, Richard M. Goldberg, Michael J. Hall, Aaron James Scott, Mohd Khushman, Jimmy J. Hwang, Emil Lou, Benjamin A. Weinberg, John Marshall, Albert Craig Lockhart, Phillip Stafford, Jian Zhang, W. Michael Korn, Heinz-Josef Lenz


Alteration of the DDR pathway was strongly associated with MSI status in CRC. • DDR-MT was more prevalent in right-sided tumors compared to left-sided tumors. • Elevated TMB and PD-L1 expression in DDR-MT CRC indicate more activated anti-tumor immune profiles compared to DDR-WT, regardless of MSI status, suggesting possible therapeutic benefit from immune checkpoint inhibitors in DDR-MT CRC.

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