Small non-coding RNA profiling from prostate cancer plasma by deep sequencing


Xianghua Liu, Andrew W. Hunter, Qing Zhang, Quanyuan He, Annemarie Benton, Gerri Ortiz, Vaishali Pannu, Nick Xiao, Mark R. Miglarese, David B. Spetzler

Prostate cancer (PCa) is the most common non-skin cancer among American men. MicroRNAs (miRNAs) are critical posttranscriptional regulators and involved in prostate cancer tumorigenesis. The aim of this study is to identify a PCa-specific expression profile of miRNAs from plasma to guide prostate cancer diagnosis and therapeutic treatment.

  • We discovered a unique expression profile of miRNA detectable in the plasma from prostate cancer patients.
  • Extracted RNA from the pellets of anti-Ago2 immunoprecipitations can enhance the detection of miRNA.
  • Expand study to confirm these findings are needed.

Download Publication