S1314 correlative analysis of ATM, RB1, ERCC2 and FANCC mutations and pathologic complete response (pT0) at cystectomy after neoadjuvant chemotherapy (NAC) in patients with muscle invasive bladder cancer (MIBC): implications for bladder preservation


Elizabeth R. Plimack, Catherine Tangen, Melissa Plets, Rutika Kokate, Joanne Xiu, Chadi Nabhan, Eric A. Ross, Erin Grundy, Woonyoung Choi, Colin P.N. Dinney, I-Ling C. Lee, Scott Lucia, Thomas W. Flaig, David James McConkey


We previously reported that MIBC harboring mutations in one or more of ATM , RB1 or FANCC is exquisitely responsive to platinum based NAC, resulting in a high rate of pathologic complete response (pT0) and excellent OS and DFS after surgery.

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