RNA expression-based hypoxia score as a prognostic and predictive biomarker in hepatocellular carcinoma HCC

Authors:

Ashton Connor, Harris Krause, Brandee Price, Andrew Elliott, Moh’d Khushman, Emil Lou, Emmanuel Antonarakis, Sanjay Goel, Maen Abdelrahim, Sudha Kodali, Ashish Saharia, Rafik Ghobrial, George Sledge, Andrew Barbas

Background

  • Hepatocellular carcinoma (HCC) has rising incidence and mortality rates.
  • Tumor hypoxia is important in HCC pathogenesis but has not been effectively translated into practice.
  • We studied whether an RNA expression-based hypoxia score (HS) can serve as a prognostic and predictive biomarker in HCC.
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