Ras family mutation patterns in a large cohort of CRCs


Joanne Xiu, Wafik S. El-Deiry, Paul M. Campbell, Lanlan Zhou, James S. Duncan, Zoran Gatalica, Sandeep K. Reddy, Jonathan Chernoff, Steven J. Cohen


KRAS, NRAS and HRAS are functionally and structurally close proto-oncogenes with conserved sequences at important functional regions. Mutated Ras family members promote oncogenesis, cause cell proliferation and survival and confer resistance to anti-EGFR therapy. We hypothesized Ras family mutations have variable molecular and clinical features including in metastasis of CRC.

Download Publication