Novel panomic validation of time to next treatment (TNT) as an effective surrogate outcome measure in 4,729 patients


John Marshall, Lee Schwartzberg, Gerold Bepler, David Spetzler, Wafik El-Deiry, Nick Xiao, Sandeep Reddy, James Symanowski, Edward S. Kim, George Poste, Derek Raghavan


In an era increasingly focused on the value of medicine, attempts are being made to improve the cost effectiveness of many aspects of medical management (1-2). One potential solution is precision medicine, which uses predictive biomarkers to guide treatment selection to improve outcomes by reducing the use of drugs that are likely to be of little benefit (3).

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