Multiplatform molecular profiling of 2,400 pancreatic adenocarcinomas to identify targets for therapeutic intent

Authors:

Sherri Z. Millis, PhD, David Arguello, MD, Maeve A. Lowery, MD, Eileen M. O'Reilly, MD

Background

Pancreas adenocarcinoma (PC) is a challenging disease with overall single digit 5-year survivorship. Few validated biomarkers exist for directing treatment in PC. Only one targeted agent (erlotinib) is FDA approved and was developed in an unselected population (Moore, et al, J Clin Oncol, 2007). Identification of individual PC genomic and phenotypic profiles may yield targets with novel therapeutic application.

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