Multi-omic characterization of gastrointestinal stromal tumor (GIST) in a large real-world patient cohort


Jonathan Trent, David Gómez-Peregrina, Andrew Elliott, Sosipatros Boikos, Vaia Florou, Margaret vonMehren, John Charlson, Gabriel Tinoco, Robert Maki, Suzanne George, Aditi Dhir, Daruka Mahadevan, Matthew Oberley, George Sledge, Gina D’Amato, Cesar Serrano


  • This series provides unprecedented resolution of KIT/PDGFRA mut GIST with features of clinical aggressiveness associated with KIT exon 11 indels and resistance mutations, illustrating a specific cytogenetic genotype with more aggressive growth and malignant behavior.
  • Identification of less common molecular alterations that drive kinase activation and impaired DNA damage repair warrant further investigation.
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