Molecularly-guided therapeutic options beyond TKIs for Gastrointestinal Stromal Tumors (GIST)


Rebecca Feldman, PhD, Zoran Gatalica MD, DSc, Sandeep Reddy MD, Kamalesh Sankhala, MD


GISTs are characterized by KIT/PDGFRA mutations. A range of multi-targeted tyrosine kinase inhibitors (TKIs) are available for treatment, however, resistance mechanisms inevitably emerge.
Recent data (Boichuk, et al 2014) suggests the potential efficacy of various cytotoxic therapies that were identified as being able to effectively kill TKI-responsive and -resistant GIST cells. We sought to investigate the theranostic markers associated with non-TKI therapy options for their potential role in treatment of GIST.

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