Molecular profiling of bile duct and gallbladder cancer to identify different therapeutic options


Randall F. Holcombe, Joanne Xiu, Zoran Gatalica, Michael A. Morse


Biliary tree carcinomas arising in different anatomic locations (intrahepatic IHBC; extrahepatic, EHBC) and gallbladder (GBC) are rare tumors with a poor prognosis. An unmet medical need exists in identifying biomarkers of drug response. We interrogated biomarkers from a large cohort of patient samples with a multiplatform approach and considered associated therapeutic options.

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