Molecular profiling of bile duct and gallbladder cancer to identify different therapeutic options

Authors:

Randall F. Holcombe, Joanne Xiu, Zoran Gatalica, Michael A. Morse

Background

Biliary tree carcinomas arising in different anatomic locations (intrahepatic IHBC; extrahepatic, EHBC) and gallbladder (GBC) are rare tumors with a poor prognosis. An unmet medical need exists in identifying biomarkers of drug response. We interrogated biomarkers from a large cohort of patient samples with a multiplatform approach and considered associated therapeutic options.

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