Molecular drivers of organotropism and cisplatin resistance in germ cell tumors


Aditya Bagrodia, Yun Sawa, Liwei Jia, Harris Krause, Fred Millard, Alex Patrick Farrell, Andrew Elliott, John T. Lafin, Christina Jamieson, Emmanuel S. Antonarakis, Anishka D'Souza, James F. Amatruda, Siamak Daneshmand, Rana R. McKay, Matthew James Oberley, Chadi Nabhan


  • There are no molecular alterations associated with site of metastasis: KIT mutations are more prevalent in primary tumors and TP53 mutations more prevalent in metastases
  • No recurrent alterations were associated with platinum-resistance
  • In chemotherapy-naïve tumors, significantly lower platinum sensitivity scores were associated with platinum-resistant alterations
  • Limitations of this study include the small sample size and lack of clinical follow-up
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