Molecular and immune characterization of squamous cell ovarian cancers for identification of therapeutic targets



  • Squamous cell carcinoma (SCC) represents <1% of all Ovarian cancers (OC) and is associated with poor prognosis
  • It is thought to arise predominantly from malignant transformation of mature cystic teratomas (MCT) but can also arise from Brenner’s tumors (BT) and endometriosis
  • This study seeks to identify prognostic factors and molecular markers associated with OSCC compared to Endometrioid OC (EOC), Clear Cell OC (CCOC), HPV16/18-negative vulvar SCC (VSCC) and HPV16/18-negative cervical SCC (CSCC)
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