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Globo H Expression in Metastatic Colorectal Cancer (CRC)

Authors:

Priya Jayachandran, Yasmine Baca, Joanne Xiu, Jian Zhang, Francesca Battaglin, Hiroyuki Arai, Richard M. Goldberg, Benjamin Adam Weinberg, Emil Lou, Michael J. Hall, Moh'd M. Khushman, Davendra Sohal, Shivani Soni, Jingyuan Wang, Wu Zhang, Joshua Millstein, Wolfgang Michael Korn, Heinz-Josef Lenz

Background: Globo H is a carbohydrate antigen that is highly expressed on the cell surface of epithelial cancers but not in normal tissue, and has been reported to correlate with poor prognosis. An attractive therapeutic target, Globo H-targeted agents are being tested in early clinical trials (e.g., OBI-833, a Globo H antigen conjugated to a mutated diphtheria toxin with potential antineoplastic activities, and OBI-999, an antibody-drug conjugate (ADC) consisting of a Globo H monoclonal antibody with a synthetic antineoplastic agent). We aim to describe the molecular features associated with Globo H expression in CRC.

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