Frequency of BRCA mutations and co-occurring alterations in prostate cancer


Charles E. Myers, M.D., Rebecca Feldman, Ph.D., Brian L. Abbott, M.D., Sandeep K. Reddy, M.D., Michael Castro, M.D.


Background: Evidence is building for the utility of PARP (oral poly (ADP-ribose) polymerase) inhibitors in BRCA-mutated patients, across solid tumors. We examined the presence of somatic BRCA mutations (detected in tumor), in a population of prostate cancer patients. Comparisons between BRCA-mutated and BRCA-wildtype patients were made to determine potential combination strategies.

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