Distinct biomarker features in triple-negative breast cancer metastases to the brain, liver, and bone


Joanne Xiu, Zoran Gatalica, Sandeep Reddy, James Waisman, John Link

Background: Triple-negative breast cancer (TNBC) is characterized by its aggressive nature and accounts for a disproportionate number of metastatic disease cases and breast cancer-related deaths. Despite recent improvements,
TNBC patients who develop metastatic diseases have limited treatment options. We investigated biomarkers from brain, liver and bone metastases collected from TNBC patients to identify therapeutic options and to examine molecular
differences between the metastatic sites.

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