Differences in the genomic and transcriptomic landscapes of Human Papillomavirus HPV-positive neuroendocrine neoplasms and HPV-positive carcinomas


Emil Lou, Harris Benjamin Krause, Andrew Elliott, Marya Wahidi, Janet Rader, Deanna Teoh, Soo Park, John Wallbillich, David Benjamin, Arash Rezazadeh, Penelope Duerksen-Hughes, Robert Morris, Radhika Gogoi, Fadi Zaiem, Thomas Herzog, Premal Thaker, Matthew Oberley, Heloisa Soares, Rouba Ali-Fehmi


  • HPV is an infectious cause of several malignancies. Neuroendocrine neoplasms (NEN) are highly heterogeneous, ranging from lowgrade indolent tumors to high-grade clinically aggressive carcinomas.
  • Aside from cervical NENs, most have not traditionally been associated with HPV, but our initial studies uncovered a subset of NENs that are HPV 16/18 positive.
  • To identify actionable differences between HPV+ NEN and non-NENs, genomic and transcriptomic landscapes were investigated.
Download Publication