Comprehensive profiling of renal medullary and collecting duct carcinomas


Thai H. Ho, Jeffrey Swensen, John McGill, Anatole Gazalpour, Ondrej Hes, Melissa Stanton, Monika Joshi, Souzan Sanati, Priyanka Purnanada, David Arguello, Sandeep Reddy, Zoran Gatalica


Renal medullary carcinoma (RMC) is an aggressive malignancy affecting predominantly young African Americans with sickle cell trait (SCT) or disease (SCD), while a pathologically similar collecting duct carcinoma (CDC) affects patients without sickle cell trait. Clinical responses to chemotherapy and IL-2 in RMC/CDC are poor and novel therapies are needed.

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