Comprehensive molecular analysis of Microsatellite-Stable (MSS) Tumors with High Mutational Burden in gastrointestinal (GI) cancers


Jingyuan Wang, Joanne Xiu, Francesca Battaglin, Hiroyuki Arai, Shivani Soni, Wu Zhang, Anthony F. Shields, Axel Grothey, Benjamin A. Weinberg, John L. Marshall, Emil Lou, Moh'd Khushman, Davendra P.S. Sohal, Michael Hall, W. Michael Korn,Heinz-Josef Lenz


This is the largest study to investigate the special molecular landscape of pts with TMB-H & MSS in GI cancers. Our data may provide novel insights for pt selection and more effective targeted combination immunotherapies (e.g. HER2, PI3K inhibitors) in MSS GI cancers.

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