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Comprehensive characterization of neurotransmitters and neuronal signaling (NT) pathway alterations in colorectal cancer (CRC)

Authors:

Francesca Battaglin, Joanne Xiu, Jia Zeng, Yasmine Baca, Priya Jayachandran, Natsuko Kawanishi, Krutika Deshpande, Richard M. Goldberg, A. Craig Lockhart, Jimmy J. Hwang, Hiroyuki Arai, Andreas Seeber, Wu Zhang, Shannon M Mumenthaler, Anthony Frank Shields, John Marshall, Wolfgang Michael Korn, Josh Neman, Heinz-Josef Lenz

Aberrant NT signaling has been shown to activate uncontrolled proliferation and dissemination in several gastrointestinal cancer types. Neurotransmitters have been shown to affect endothelial cells and immune cells in the tumor microenvironment to promote tumor progression. We previously showed that single nucleotide polymorphisms in the dopamine and GABA pathways are associated with outcome in patients with metastatic CRC receiving first-line treatment. Here we further evaluated the distribution and molecular context of NT pathway alterations in CRC.

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