Comprehensive characterization of FGF/FGFR alterations in invasive breast cancers


Kush C. Gaur1, Justin Tiu-Lim1, Julie McGrath3, Phil Walker3, Wolfgang Michael Korn3, Joanne Xiu3, Arielle Heeke4, Virginia Kaklamani5, Antoinette Tan4, Janice Lu1, Darcy Spicer1, Evanthia T. Roussos Torres5, Priya Jayachandran2, Audrey Saghian2, Amir Goldkorn2, Irene Kang2 1. University of Southern California, Keck School of Medicine, Los Angeles, CA 2. USC Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 3. Caris Life Sciences, Phoenix, AZ 4. Levine Cancer Institute, Atrium Health, Charlotte, NC 5. UT Health San Antonio, MD Anderson Cancer Center, San Antonio, TX


FGFR signaling is central for cancer cell proliferation, migration, angiogenesis and survival; FGFR alterations have become clinically actionable in increasing number of cancer types. This study evaluated the incidence and characterization of numerous FGF/FGFR alterations in over 12,000 invasive breast cancers and highlighted the tremendous heterogeneity of FGF/FGFR alterations in various histologic and molecular subtypes as well as different metastatic sites of breast cancer. Further, the associations of FGFR alterations and resistance to therapies were shown in a large clinical database with matched molecular results.

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