Characterization of NRG1 gene fusion events in solid tumors


Sushma Jonna, Rebecca Feldman, Sai-Hong Ignatius Ou, Misako Nagasaka, Jeffrey Swensen, Wolfgang Michael Korn, Hossein Borghaei, Ari M. Vanderwalde, Gilberto Lopes, Jorge J. Nieva, Alexander I. Spira, Edward S. Kim, Stephen V. Liu


In a much larger sample, the incidence of NRG1 fusions across tumor types remained 0.2% (82/44,570). • There is notable variation within NRG1 fusions across tumors. The biologic and clinical significance of this heterogeneity is unclear. • Therapeutic studies should incorporate NRG1 fusion variants in any efficacy results.

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