Age as a factor in the molecular landscape and the tumor-microenvironmental signature of osteosarcoma


Andreas Seeber, Andrew Elliott, Jaime Modiano, Gerold Untergasser, Margaret von Mehren, Andrew Rosenberg, Moh’d Khushman, Don S. Dizon, Richard F. Riedel, Jonathan C. Trent, Kai Zimmer, Galina Lagos, Bradley DeNardo, Aaron Sarver, Alberto Puccini, Phillip Walker, Matthew James Oberley, Wolfgang Michael Korn, Domink Wolf, Florian Kocher

Key Finding:

A comparison of tumors from younger versus older osteosarcoma patients demonstrates differences in the mutational landscape and tumor microenvironment composition, including increased gene amplifications in younger patients and decreased B-cell abundance in older patients. 

Download Publication