Molecular and genomic characterization of SCLC


Stephen Liu, Edward Kim, Rebecca Feldman, Zoran Gatalica, Jeffrey Swensen, Hossein Borghaei, Alexander Spira, Gerald Bepler, Sandeep Reddy, Afshin Dowlati

Introduction: Small cell lung cancer (SCLC), strongly tobacco-associated, has been described to have a heavy mutation burden, harboring high rates of TP53 and RB1 alterations. While initially responsive to radiation and chemotherapy,
SCLC is characterized by eventual progression and resistance to traditional therapy. We retrospectively analyzed a molecular profiling (MP) database to identify potentially actionable alterations using a multi-platform approach
which includes massively parallel sequencing.

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