Incidence of ERBB gene fusions (EGFR, ERBB2, ERBB4) across tumor types


Laura Schubert, Andrew Elliott, Robert Charles Doebele, Emil Lou, Hossein Borghaei, Michael J. Demeure, Razelle Kurzrock, Anh T. Le, Joshua E. Reuss, Sai-Hong Ignatius Ou, David R. Braxton, Christian A. Thomas, Sourat Darabi, Wolfgang Michael Korn, Wafik S. El-Deiry, Stephen V. Liu

Background: Gene fusions often represent critical therapeutic targets across cancer subtypes. Fusions within the ErbB family of receptor tyrosine kinases, including EGFRERBB2 (HER2) and ERBB4 (HER4), have been previously described and represent potentially actionable alterations. Here, we report the relative incidence and functional characterization of these rare genomic events.

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