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Genomic and immunologic characterization of large-cell neuroendocrine carcinoma of the lung.

Authors:

Chul Kim, Julie Elaine McGrath, Joanne Xiu, Misako Nagasaka, Patrick C. Ma, Jorge J. Nieva, Gilberto Lopes, Hossein Borghaei, Chukwuemeka Ikpeazu Sr., Taofeek K. Owonikoko, Michael J. Demeure, Antoinette J. Wozniak, Chadi Nabhan, Wolfgang Michael Korn, Stephen V. Liu

Background: Large-cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer with a poor prognosis. Due to its rarity, molecular characterization of LCNEC is not well elucidated. We aim to understand the genomic and immunologic landscape of LCNEC to identify molecular alterations and relevant biological pathways with potential therapeutic value.

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