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Jonathan Knowles, PhD

  • Vice Chairman, Caris Life Sciences
  • Professor, Translational Medicine, Ecole Polytechnique Fédérale de Lausanne, Switzerland
  • Visiting Professor, Division of Medicine, University of Oxford
  • Distinguished Professor, Personalized Health Care, Finnish Institute for Molecular Medicine, University of Helsinki
  • Former President of Group Research, Roche Pharmaceuticals
  • Former Member of Board of Directors, Genentech
  • First Chairman of the Board, Innovative Medicines Initiative
  • Recipient of the Scrip Lifetime Achievement Award (2010)

Jonathan Knowles, PhD, joined the Caris Life Sciences™ (Caris) Board of Directors on September 1, 2009 and accepted the position of vice chairman starting on January 1, 2010. Dr. Knowles’ distinguished career has spanned decades in both academia and the pharmaceutical industry, including his most recent role as president of group research at Roche, a position he has held since 2007, and member of that organization’s Corporate Executive Committee, which he has held since 1998. Dr. Knowles was also a member of the Genentech Board for the last 12 years and a member of the Chugai Board for seven years.

Additionally, Dr. Knowles was the chairman of the Corporate Governance Committee of Genentech. He was for five years the chairman of the Research Directors’ Group of EFPIA (European Federation of Pharmaceutical Industry Associations) and was the first chairman of the Board of the Innovative Medicines Initiative, a unique public-private partnership between 28 Pharmaceutical companies and the European Commission with a budget of more than 2 Billion Euros over five years. Dr. Knowles focused the company on key disease biology areas of high medical need and in-depth understanding of molecular pathology of disease. Under his leadership, the company developed and implemented a strategy of highly effective therapies based on personalized healthcare and built one of the best pharmaceutical pipelines in the sector.

Dr. Knowles attended Magdalen College School in Oxford and received a first class honours degree in molecular genetics from the University of East Anglia in Norwich, England. He received his PhD in genetics of mitochondria with Professor G. H. Beale FRS from the University of Edinburgh in Scotland.

In 2010, Dr, Knowles was awarded the Scrip’s Lifetime Achievement Award for his long academic and commercial career distinguished by his passion for personalized medicine.

Jonathan Knowles also holds the post of professor of translational medicine at Ecole Polytechnique Fédérale de Lausanne in Switzerland, has been awarded a distinguished professorship in personalized health care at the Finnish Institute for Molecular Medicine at the University of Helsinki, and has been appointed as a visiting chair at the University of Oxford. In addition, he is a member of the European Molecular Biology Organization and a William Pitt Fellow of Pembroke College Cambridge.