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Research Proposal Inquiry

The Caris Life Sciences Letter of Intent process empowers members of the Caris Precision Oncology Alliance® (POA®) to advance innovative, investigator-initiated research. The program is open to academic and community-based physicians and researchers worldwide who are interested in pursuing independent scientific studies which impact patient care and/or contribute to filling a gap in the biological knowledge of cancer.
 
Participation begins with submission of an inquiry describing the proposed research concept. Inquiries are evaluated based on data availability, test-ability of the hypothesis and lack of overlap with other approved projects. Selected investigators may be invited to submit a Letter of Intent (LOI) full research proposal for further review. Submission of an LOI proposal does not guarantee approval, and all proposals are assessed by the Caris Scientific Review Committee.
 
Caris is committed to supporting high-quality research and expects all approved studies to result in publication. Any support is contingent upon the successful execution of a research agreement between both parties.

IMPORTANT NOTICE:

Due to the high volume of submissions for ASCO Annual 2027, Research Proposal Inquiries submitted between September 2, 2026, and January 31, 2027, may experience substantially extended review times. Regular review of new inquiries will resume in February 2027.

Important Information Regarding ASCO Annual 2027


Key steps and deadlines for ASCO Annual 2027:

  1. Submit a hypothesis-driven Research Proposal Inquiry by September 1, 2026.
    Selected inquiries may be invited to submit a full Letter of Intent (LOI) for further review.
    1. Research Proposal Inquiries submitted after September 1, 2026, will not be reviewed until late February 2027.
  2. If requested, provide background slides by October 1, 2026.
  3. If the project receives scientific endorsement, a fully executed contract must be in place by January 8, 2027.

Please review the ASCO 2027 LOI Submission Guidance process and the Letter of Intent submission process for complete details. 

As with all research organizations, our resources are finite. Here are some tips to increase the chance of your proposal to be approved.


Research that we prioritize:

  • Hypothesis-driven studies
  • Strong data or scientific foundations
  • Innovative and translational relevance


Common reasons for rejection:

  • Limited data availability in the Caris database for your proposed research question.
  • Overlap with ongoing or completed Caris projects.
  • Broad Exploratory Descriptive studies without testable hypotheses.
  • Upon submission of the inquiry, the Caris research team will conduct an initial review and contact you for the next steps.
  • Due to the high volume of submissions for ASCO Annual 2027, Research Proposal Inquiries submitted between September 2, 2026, and January 31, 2027 will experience substantially extended review times.
  • Regular review of new inquiries will resume in February 2027.
  • For approved inquiries, a link to proceed with the full proposal submission will be provided.

Please visit our LOI resource page for more details.

A few reminders to help set your project up for success:

  • CODEai is a powerful clinico-genomic platform for exploring the Caris database. Please ensure you are familiar with the platform before generating results.
  • Our Clinical & Translational Research team is here to help. Please consult with the team before carrying out in-depth analysis or preparing an abstract or manuscript to confirm your cohort design and study approach.
  • To support scientific quality and compliance, only projects that have been vetted and approved by Caris CTR are eligible for conference or journal submission.