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Caris Pathology Program

Precision Medicine Begins with Pathology, Powered by Expertise and Driven by Data. 

Caris Life Sciences® is an organization built on pathology excellence and a foundation of comprehensive diagnostic standards and innovation. Our pathology program drives precision oncology by combining expert interpretation with advanced molecular profiling technologies. 

Comprehensive Pathology Program Overview 

Molecular Profiling Services 

  • Whole Exome Sequencing (WES) and Whole Transcriptome Sequencing (WTS) 
  • Identification of mutations, fusions and copy number alterations across 23,000+ genes 
  • Supports broad biomarker discovery for research and clinical applications 

Digital Pathology Capabilities 

  • Access to 5.6 million+ digitized pathology slides 
  • Fully digitized, AI-enabled workflow allowing nationwide collaboration 
  • AI-driven tools to assist with therapy response prediction and trial matching 

Clinico-Genomic Data Resources 

  • Database of over 790,000 matched molecular profiles and outcomes 
  • Integration of genomic, transcriptomic, proteomic and clinical data for comprehensive insights 

Caris Pathology by the Numbers 

23K+ Genes

Whole Exome
Whole Transcriptome

5.6MM+

Digitized Pathology Slides

790,000+

Matched Molecular
Profiles and Outcomes

Our Pathology Team – Precision Medicine with Human Insight 

Behind every innovation at Caris is a team of pathologists who never forget the human side of science. Our 31 board-certified anatomic and clinical pathologists combine deep subspecialty expertise with advanced AI and digital pathology to bring clarity to complexity and confidence to patient care. 

Pathologists are the clinical and molecular translators of patient care. We provide physician-to- physician consultation for our ordering providers. From resolving diagnostic uncertainty to integrating tissue and blood profiling, our team ensures that precision medicine is more than a process, it is a partnership. 

At Caris, pathology is not a checkpoint, it is the cornerstone of precision medicine. Our specialized pathologists bring deep expertise to ensure every result is grounded in diagnostic accuracy and clinical context, transforming molecular data into actionable insights for patient care.”

Matthew Oberley, MD, PhD
SVP, Chief Clinical Officer, Pathologist-in-Chief

Matthew Oberley, MD, PhD
SVP, Chief Clinical Officer, Pathologist-in-Chief

31 Board-Certified Pathologists with nationwide licensure and subspecialty expertise including: 

Matthew James Oberley, MD, PhD

Chief Clinical Officer and
Pathologist-in-Chief
Hematopathology

David A. Bryant, MD

Executive Medical Director, Pathology

Anatomic/Clinical Pathology and Genitourinary Pathology 

Jaclyn F. Hechtman, MD

Medical Director, Pathology

Gastrointestinal Pathology and Molecular Genetic Pathology

Patricia Danielle Pittman, MD, MBA

Medical Director, Pathology

Neuropathology 

Ahmed S. Bedeir, MD

Oncologic Pathologist
Gastrointestinal and Molecular Pathology

Amy Adams, MD

Oncologic Pathologist

Breast Pathology

Angela Raquel McGuire, MD

Director, Pathology
Forensic Cardiovascular, Neuropathology and Molecular Genetic Pathology

Caleb Cheng, MD, MBA

Director, Pathology

Breast and Gynecologic Pathology

Christian Davidson, MD

Oncologic Pathologist
Neuropathology 

Christina Irene Fredenberg, MD

Oncologic Pathologist 

Cristina Maria Ramirez, MD

Oncologic Pathologist 

Cyrus D. Oster, MD

Oncologic Pathologist

Hematopathology

Donna Catherine Ferguson, MD

Oncologic Pathologist

Molecular Genetic Pathology

Hany Magharyous, MD

Oncologic Pathologist

Molecular Genetic Pathology

Hassan Ghani, MD

Physician Scientist

Molecular Genetic Pathology

Janice Seulgy Ahn, MD

Oncologic Pathologist

Neuropathology 

Joaquin Ponce-Zepeda, MD

Oncologic Pathologist

Cytopathology and Molecular Genetic Pathology

John C. Blaustein, MD

Senior Oncologic Pathologist Hematopathology

Joon Yim, MD 

Oncologic Pathologist
Gastrointestinal, Genitourinary and Gynecologic Pathology

Jose L. De Los Santos, MD

Oncologic Pathologist

Cytopathology

Kelly E. Craven, MD, PhD

Oncologic Pathologist

Molecular Genetic Pathology

Kurt B. Hodges, MD, MB

Oncologic Pathologist

Molecular Genetic Pathology

Mark Evans, MD

Director, Molecular Pathology

Molecular Genetic Pathology and Hematopathology

Matthew Crabtree, MD, MS

Oncologic Pathologist

Hematopathology

Mylinh T. Mac, MD

Oncologic Pathologist

Hematopathology, Gastrointestinal, Liver and Oncologic Surgical Pathology

Oliver A. Press, MD

Oncologic Pathologist

Cytopathology

Qingmei Xie, MD

Oncologic Pathologist
Hematopathology

Rachel Jug, MD

Oncologic Pathologist

Cytopathology

Wen-Hsiang Wen, MD, PhD

Senior Oncologic Pathologist

Molecular Genetic Pathology

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Be Sure with Caris Assure

Caris Assure® is a minimally invasive blood test that utilizes circulating Nucleic Acid Sequencing (cNAS) to analyze cell-free DNA and RNA from plasma, plus genomic DNA and messenger RNA from circulating white blood cells (WBCs), to distinguish somatic tumor, incidental clonal hematopoiesis (CH) and incidental germline variants.

MI Profile Comprehensive Molecular Profiling

MI Profile® comprehensive testing delivers Whole Exome Sequencing (WES – DNA) and Whole Transcriptome Sequencing (WTS – RNA) for 23,000+ genes, as well as protein analysis and AI-predictive algorithms. MI Profile is designed to reveal a complete molecular blueprint that can guide more precise and individualized treatment decisions and help improve patient outcomes.

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