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Home / Research / Publications / Prognostic and predictive effects of TP53 co-mutations and RET fusion partners in RET-rearranged advanced NSCLC

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Prognostic and predictive effects of TP53 co-mutations and RET fusion partners in RET-rearranged advanced NSCLC

Key Findings:

  • Clinico-genomic analyses of tumors from patients with RET-rearranged advanced NSCLC treated with selective RET inhibitors demonstrated correlations between outcomes and genomic features. 
  • TP53 co-mutation was associated with shorter progression-free and overall survival, indicating adverse prognostic significance. 
  • RET fusion partner was associated with differences in clinical outcomes. 
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