Key Finding:
FH A41V is the most common variant of unknown significance and is associated with worse survival after chemotherapy compared to other Pathogenic and Likely Pathogenic mutations.
– Caris Life Sciences
Abstract Purpose: 10-15% of prostate cancers (PCa) harbor recurrent FOXA1 aberrations whereby the alteration type and the effect on the forkhead( FKH) domain impacts protein-function. We developed… […]
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