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Home / Research / Publications / Distinct late recurrence patterns and immune landscape of HER2-positive invasive lobular carcinoma (ILC):Analysis of NCCTG N9831 (Alliance) trial and real-world cohort

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Distinct late recurrence patterns and immune landscape of HER2-positive invasive lobular carcinoma (ILC):Analysis of NCCTG N9831 (Alliance) trial and real-world cohort

Key Findings

ey Findings from this Session

  • Analysis of the NCCTG N9831 trial, with validation in a real-world Caris cohort, showed that HER2-positive ILC demonstrated increased late recurrence risk despite initial trastuzumab benefit and exhibited a distinct immune landscape.
  • Thise study demonstrate how transcriptomic and clinico-genomic analyses can identify distinct biological and immune features in breast cancer, potentially supporting more personalized approaches to risk stratification and therapeutic development.
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