Key Findings
- Adult NTRK-rearranged sarcomas are exceedingly rare, identified in only 0.15% of 13,040 sequenced sarcomas.
- Most of these tumors present as high grade disease and are frequently metastatic at diagnosis, with broad anatomic distribution and morphologic diversity.
- Recognition of their histologic spectrum and molecular confirmation is critical for accurate classification and therapeutic decision-making, particularly given the activity of TRK inhibitors across fusion types.