cBioPortal for Cancer Genomics is an open-source platform for interactive, exploratory analysis of large-scale clinicogenomic
data.
The site (https://www.cbioportal.org) hosts data from >390 studies from individual labs and large consortia, including
AACR Project GENIE, which contains >197,000 clinically sequenced samples with clinical annotations like response,
outcome, and treatment history.
A suite of user-friendly visualizations and analyses, including OncoPrints, mutation lollipop plots, variant interpretation,
group comparison, survival analysis, expression correlation analysis, alteration enrichment analysis, and cohort and patientlevel
visualization, enable comprehensive exploration of these data.
cBioPortal is an open source, collaborative effort among groups at Memorial Sloan Kettering Cancer Center, Dana-Farber
Cancer Institute, Childrens Hospital of Philadelphia, Princess Margaret Cancer Centre, Caris Life Sciences, Bilkent University
and The Hyve.
Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay
Abstract The precision oncology industry has evolved rapidly within the past two decades, although treatment selection remains a complex undertaking. Access to timely, accurate, and… […]
Comparison of trastuzumab deruxtecan and sacituzumab govitecan in HER2-negative metastatic breast cancer: a large real-world data analysis
Abstract Background Trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) are antibody-drug conjugates (ADCs) increasingly used in HER2-negative breast cancer. We hypothesized that treatment benefit would… […]
