cBioPortal for Cancer Genomics is an open-source platform for interactive, exploratory analysis of large-scale clinicogenomic
data.
The site (https://www.cbioportal.org) hosts data from >390 studies from individual labs and large consortia, including
AACR Project GENIE, which contains >197,000 clinically sequenced samples with clinical annotations like response,
outcome, and treatment history.
A suite of user-friendly visualizations and analyses, including OncoPrints, mutation lollipop plots, variant interpretation,
group comparison, survival analysis, expression correlation analysis, alteration enrichment analysis, and cohort and patientlevel
visualization, enable comprehensive exploration of these data.
cBioPortal is an open source, collaborative effort among groups at Memorial Sloan Kettering Cancer Center, Dana-Farber
Cancer Institute, Childrens Hospital of Philadelphia, Princess Margaret Cancer Centre, Caris Life Sciences, Bilkent University
and The Hyve.
Key Points Question Can an artificial intelligence–assisted approach integrated into the routine molecular profiling workflow differentiate lung squamous cell carcinoma (SCC) from metastases of other origins?… […]
A Three-subtype Molecular model of Cervical Cancer: Multiple PI3K Pathway inhibitors suppress growth and cooperate with HPV-directed immunotherapy
Abstract Objective Cervical cancer is caused by human papillomavirus (HPV) infections; however, there are no molecularly defined subtypes, and few approved targeted therapies. We defined molecular… […]
