Fusion analysis of solid tumors to reveal novel rearrangements in breast carcinomas

Authors:

Igor Astsaturov, Philip Ellis, Jeff Swensen, Zoran Gatalica, David Arguello, Sandeep Reddy, Wafik El-Deiry

Introduction to gene fusion
• Fusions of genes are common events in epithelial cancers
• Recurrent fusions arise as the result of genomic rearrangements or abnormal processing of mRNA
• Proteins translated from gene fusions are potential drug targets

Download Publication