Key Findings
- Analysis of 3,913 renal cell carcinoma samples profiled by Caris identified distinct genomic and hypoxia-associated transcriptional
features in brain metastases, while demonstrating conserved expression of multiple actionable therapeutic targets across primary
tumors and brain metastases. - These findings demonstrate that comprehensive molecular profiling can characterize biologically distinct metastatic disease
states and support development of biomarker-informed therapeutic strategies in renal cell carcinoma.