Background: Several studies established the prognostic role of both the amount and locations of tumor-infiltrating lymphocytes (TILs) in TNBC. Three distinct immunotypes were described based on the amount and locations of TILs: immune enriched (IN), immune excluded, and immune desert. Using single-cell spatial transcriptomic analysis in the Mayo Clinic TNBC cohort, our previous studies showed the central role of interferon (IFN) signaling in IN phenotype. Herein, we evaluated the association between IFN and outcomes in TNBC in 3 independent datasets.
Publications
Interferon Signaling and Outcomes in Triple-negative Breast Cancer (TNBC) in FinXX, CALGB 40603 (Alliance) and Real-World Clinico-Genomic Data
– Caris Life Sciences