cBioPortal for Cancer Genomics is an open-source platform for interactive, exploratory analysis of large-scale clinicogenomic
data.
The site (https://www.cbioportal.org) hosts data from >390 studies from individual labs and large consortia, including
AACR Project GENIE, which contains >197,000 clinically sequenced samples with clinical annotations like response,
outcome, and treatment history.
A suite of user-friendly visualizations and analyses, including OncoPrints, mutation lollipop plots, variant interpretation,
group comparison, survival analysis, expression correlation analysis, alteration enrichment analysis, and cohort and patientlevel
visualization, enable comprehensive exploration of these data.
cBioPortal is an open source, collaborative effort among groups at Memorial Sloan Kettering Cancer Center, Dana-Farber
Cancer Institute, Childrens Hospital of Philadelphia, Princess Margaret Cancer Centre, Caris Life Sciences, Bilkent University
and The Hyve.
Introduction: Regorafenib is a third-line option in metastatic CRC, often overshadowed by its limited efficacy and high toxicity. Yet, rare cases of deep and even… […]
Effect of elevated expression of LILRB4 and TSC22D3 on survival in lung cancer
Background: LILRB4 and TSC22D3 in Inflammation HER2/neu mutations or amplifications can activate STAT3 to promote inflammation and suppressing adaptive immune responses. Elevated systemic inflammation-immune index… […]
