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Home / Research / Publications / Actionable Targets in Pancreatic Cancer Detected by Imunohistochemistry (IHC), Microarray (MA) Fluorescent in situ Hybridization (FISH) and Mutational Analysis

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Actionable Targets in Pancreatic Cancer Detected by Imunohistochemistry (IHC), Microarray (MA) Fluorescent in situ Hybridization (FISH) and Mutational Analysis

– Caris Life Sciences

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Background

A great need exists for new therapeutic approaches for patients with pancreatic cancer

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  • The mechanism of mismatch repair deficiency (MMRd) informs survival outcomes derived from immune checkpoint blockade (ICB) across MMRd solid tumors

    – Caris Life Sciences

    Manuscript

    Background MMRd/Microsatellite instability (MSI) High tumors represent the first tumor-agnostic indication for ICB. Emerging data suggest that the specific MMR protein lost and the mechanism… […]

  • Characterization of Plasma Cell-Free DNA Variants as ofTumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer Patients

    – Caris Life Sciences

    Manuscript

    Abstract Purpose: Plasma-based liquid biopsy tests can detect tumorspecific genetic alterations and offer many advantages that complement tissue-based comprehensive genomic profiling. However, age-related clonal hematopoiesis… […]
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