Key Findings
- Transcriptomic analysis of 49,144 tumors profiled by Caris identified an HGNEC-like subset of NSCLC with poor survival, immune
suppression, and enrichment of targetable neuroendocrine-associated biomarkers. - This study highlights how comprehensive molecular profiling can uncover clinically relevant molecular subgroups, prognostic biomarkers, and therapeutic targets across diverse tumor types, supporting more precise biomarkerdriven research and treatment strategies.