Key Findings from this Session
- Molecular profiling of 4,863 neuroendocrine carcinomas by Caris revealed that GEP-NECs exhibit a distinct and relatively immunosuppressive tumor microenvironment compared to thoracic-NECs, with B-cell, NK-cell, and macrophage signatures associated with survival across disease subtypes.
- These findings show how comprehensive molecular profiling and immune microenvironment analysis can identify prognostic immune signatures in rare cancers, supporting biomarker-driven therapeutic development in GEP-NEC.