Key Findings from this Session
- Analysis of 30,887 CRCs profiled by Caris identified mtDNA-encoded oxidative phosphorylation gene expression as a marker of distinct metabolic and immune tumor states, with mtDNA-low tumors associated with improved outcomes with immunotherapy.
- This study demonstrates the value of comprehensive molecular profiling in identifying biologically distinct colorectal cancer subgroups and potential biomarkers of immunotherapy sensitivity, including in microsatellite stable (MSS) disease.