Background
NTRK1/2/3 gene fusions are oncogenic drivers in multiple tumor types and define several well-characterized pediatric neoplasms.
NTRK-rearranged mesenchymal tumors in adults are rare and their clinicopathologic spectrum remains incompletely defined.
Identification of NTRK fusions has therapeutic significance given the availability of selective TRK inhibitors.
This study examines the clinicopathologic features and genomic context of adult NTRK-rearranged sarcomas to better define their morphologic spectrum.