Background
- FAP and SPP1 contribute to immune modulation inthe CRC tumor microenvironment (TME).
- FAP is expressed by cancer associated fibroblasts,aiding in tissue remodeling and tumor invasion.
- SPP1 is an integrin-binding protein expressed bytumor associated macrophages that promotestumor growth, adhesion, and metastasis.
- We present a clinical and molecularcharacterization of FAP and SPP1 in CRC.