Clinical and Molecular Characterization of FAP and SPP1 in Colorectal Cancer (CRC), CALGB (Alliance)/SWOG 80405 and Real-world Data | Caris Life Sciences
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Clinical and Molecular Characterization of FAP and SPP1 in Colorectal Cancer (CRC), CALGB (Alliance)/SWOG 80405 and Real-world Data

Background

  • FAP and SPP1 contribute to immune modulation inthe CRC tumor microenvironment (TME).
  • FAP is expressed by cancer associated fibroblasts,aiding in tissue remodeling and tumor invasion.
  • SPP1 is an integrin-binding protein expressed bytumor associated macrophages that promotestumor growth, adhesion, and metastasis.
  • We present a clinical and molecularcharacterization of FAP and SPP1 in CRC.
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