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Multi-omic analysis reveals distinct molecular profiles of uterine and non-uterine leiomyosarcoma

Authors:

Tabitha Copeland, Roman Groisberg, Don S. Dizon, Andrew Elliott, Galina Lagos, Andreas Seeber, Margaret von Mehren, Kenneth Cardona, Michael J. Demeure, Richard F. Riedel, Vaia Florou, Alexander J. Chou, Abhijeet Kumar, Jaime Modiano, Moh'd M. Khushman, Gina Z. D'Amato, Andrea P. Espejo Freire, W. Michael Korn, Jonathan C. Trent

Background: Leiomyosarcoma (LMS) is a rare group of mesenchymal malignancies found in the uterus, retroperitoneum, skin, or other soft-tissue sites. Treatment for LMS is extrapolated from trials including both uterine (uLMS) and non-uLMS subtypes, although whether they respond similarly and have similar outcomes from treatment is not clear. We examined the molecular composition of LMS by site of origin to better inform future drug development and trial design.

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